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Photoaffinity labeling of the angiotensin II receptor. 3. Receptor inactivation with photolabile hormone analogs

✍ Scribed by Escher, Emanuel H. F.; Guillemette, Gaetan

Book ID
126905419
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
567 KB
Volume
22
Category
Article
ISSN
0022-2623

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## Abstract The synthesis of [Sar^1^, Val^5^, (4′‐azido‐3β€²,5′‐ditritio)Phe^8^] angiotensin II from a iodinated precursor peptide is described. The principal problems of this synthesis and their resolution are discussed: (i) The β‐induced autophotolysis of the highly tritiated (73 Ci/mmol) and photo