Photoaffinity labeling of P-glycoprotein in multidrug resistant cells with photoactive analogs of colchicine
โ Scribed by Ahmad R. Safa; Nitin D. Mehta; Michael Agresti
- Book ID
- 115761591
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 664 KB
- Volume
- 162
- Category
- Article
- ISSN
- 0006-291X
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The role of cellular interactions in the resistance of Djungurian hamster cells to colchicine (CH) and in the efficiency of Pโglycoprotein function was studied. Mixtures of CHโresistant and CHโsensitive cells as well as control unmixed cells were propagated for 3 days and the sensitivity of the cell
Regulation of P-glycoprotein (Pgp) expression occurs not only at the DNA and mRNA level but also at the protein level. We showed previously that Pgp was stabilized when multidrug-resistant CH(R)C5 and SKVCR 2.0 ovarian cell lines were subjected to serum-starved or high-cell-density growth conditions