Phosphorylation of tau in apolipoprotein E-deficient mice
โ Scribed by Idit Genis; Irit Gordon; Ephraim Sehayek; Daniel M. Michaelson
- Book ID
- 116125077
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 608 KB
- Volume
- 199
- Category
- Article
- ISSN
- 0304-3940
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Apolipoprotein E (apoE)-deficient mice have learning and memory impairments that are associated with specific neurochemical changes and hyperphosphorylation of distinct epitopes of the cytoskeletal protein tau. Furthermore, such mice are highly susceptible to the sequelae of brain trauma and their a
In Alzheimer's disease (AD), a family of proteins collectively named tau are displaced from their normal association with microtubules and are found in in a hyperphosphorylated state deposited into paired helical filaments (PHFs). PHFs are the hallmark cytoskeletal pathology of the disease, and the