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Neuronal expression of human apolipoprotein E4 increases protein tau phosphorylation in transgenic mice

โœ Scribed by Ina C. Tesseur; Jo Van Dorpe; Kurt Spittaels; Chris Van den Haute; Koen Bruynseels; Fred Van Leuven


Book ID
117411645
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
188 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract Tau function is regulated by phosphorylation, and abnormal tau phosphorylation in neurons is one of the key processes associated with development of Alzheimer's disease and other tauopathies. In this study we provide evidence that phospholipid transfer protein (PLTP), one of the main li