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High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice

✍ Scribed by Atiqur Rahman; Susanne Akterin; Amilcar Flores-Morales; Milita Crisby; Miia Kivipelto; Marianne Schultzberg; Angel Cedazo-Mínguez


Book ID
116466120
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
526 KB
Volume
579
Category
Article
ISSN
0014-5793

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Apolipoprotein E (apoE)-deficient mice have learning and memory impairments that are associated with specific neurochemical changes and hyperphosphorylation of distinct epitopes of the cytoskeletal protein tau. Furthermore, such mice are highly susceptible to the sequelae of brain trauma and their a