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Phosphorylation of imidazo[2,1-b]thiazoles with phosphorus(III) halides in the presence of bases

✍ Scribed by Evgenij V. Zarudnitskii; Aleksandr A. Yurchenko; Anatolij S. Merkulov; Marina G. Semenova; Aleksandr M. Pinchuk; Andrej A. Tolmachev

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
114 KB
Volume
16
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The reaction of phosphorus(III) halides with 6‐substituted imidazo[2,1‐b]thiazoles in the presence of bases proceeds regioselectively and affords 5‐phosphinoimidazo[2,1‐b]thiazoles, useful synthons for the preparation of various P(III) and P(V) derivatives. 5‐Phosphinoimidazo[2,1‐b]thiazoles are selectively alkylated at the phosphorus or heterocyclic nitrogen atom, depending on the alkylating agent. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:648–655, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20166

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