Phosphorus NMR Spectroscopy as a Versatile Tool for Compound Library Screening
✍ Scribed by Florian Manzenrieder; Andreas O. Frank; Horst Kessler
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 440 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A variety of NMR-based methods have been devised to facilitate the screening of compound mixtures for components that bind protein drug targets. [1±6] The majority of these approaches have been developed in recent years, hand in hand with methods for generating libraries of compounds by combinatoria
## Abstract ^79^Br NMR spectroscopy has been used to monitor a series of reactions in which the bromide ion is produced, including the Menschutkin reaction of pyridine with a range of substituted benzyl bromides and a Heck coupling process. In cases where the process could also be monitored using ^
## Abstract __Pseudomonas putida__ strain KT2442, harbouring the pWW0 TOL plasmid, was grown with a number of different homologous aromatic acids as carbon sources. Small samples of liquid culture supernatant were collected and directly analysed by 2D NMR spectroscopy. In all cases similar compound