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A Straightforward NMR-Spectroscopy-Based Method for Rapid Library Screening

✍ Scribed by Aloysius H. Siriwardena; Fang Tian; Schroder Noble; James H. Prestegard

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
129 KB
Volume
114
Category
Article
ISSN
0044-8249

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✦ Synopsis

A variety of NMR-based methods have been devised to facilitate the screening of compound mixtures for components that bind protein drug targets. [1Β±6] The majority of these approaches have been developed in recent years, hand in hand with methods for generating libraries of compounds by combinatorial chemistry. [7] The ability to screen such libraries rapidly and simply to identify potential leads is an important

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The potential utility of capillary electrophoresis CE as an analysis and biological assay method for rapid screening of single-component combinatory libraries is demonstrated by mimicking a 5 = 5 drug matrix. Twenty-five com-Ε½ . pounds some drugs, vitamins, metabolites, etc. that include biotin are