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Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

✍ Scribed by Christophe Verbruggen; Sofie De Craecker; Padinchare Rajan; Xian-Yun Jiao; Marianne Borloo; Keith Smith; Alan H. Fairlamb; Achiel Haemers


Book ID
108038965
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
269 KB
Volume
6
Category
Article
ISSN
0960-894X

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✍ Drauz, Karlheinz ;Koban, Hans Günter ;Martens, Jürgen ;Schwarze, Wolfgang 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB

## Abstract Dialkyl phosphonates add in a 1,2 fashion to the C = N bond in 5,5‐dimethyl‐3‐thiozolines **2** to form dialkyl __rac__‐(4‐thiazolidinyl)phosphonates **3a** – **e**. Upon hydrolysis of **3a** __rac__‐(1‐amino‐2‐mercapto‐2‐methylpropyl)phosphonic acid (**4a**), the phosphonic acid analog