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Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: Substitution of the glycine part

✍ Scribed by Katie Amssoms; Sandra L Oza; Koen Augustyns; Abdellah Yamani; Anne-Marie Lambeir; Gunther Bal; Pieter Van der Veken; Alan H Fairlamb; Achiel Haemers


Book ID
108477295
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
95 KB
Volume
12
Category
Article
ISSN
0960-894X

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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-Ο‰-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their Ξ³-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua