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Phosphonic and Phosphinic Acid Analogs of Penicillamine

✍ Scribed by Drauz, Karlheinz ;Koban, Hans Günter ;Martens, Jürgen ;Schwarze, Wolfgang

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
285 KB
Volume
1985
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

Dialkyl phosphonates add in a 1,2 fashion to the C = N bond in 5,5‐dimethyl‐3‐thiozolines 2 to form dialkyl rac‐(4‐thiazolidinyl)phosphonates 3a – e. Upon hydrolysis of 3a rac‐(1‐amino‐2‐mercapto‐2‐methylpropyl)phosphonic acid (4a), the phosphonic acid analog of penicillamine (1), is formed.

📜 SIMILAR VOLUMES

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