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Phospholipase A2 inhibitors promising in CHD

โœ Scribed by Pene, S

Book ID
120844401
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2008
Weight
164 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm