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Phospholipase A2 inhibitors in atherosclerosis: the race is on

✍ Scribed by Marshall A Corson

Book ID
117304439
Publisher
The Lancet
Year
2009
Tongue
English
Weight
263 KB
Volume
373
Category
Article
ISSN
0140-6736

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πŸ“œ SIMILAR VOLUMES

Molecular modeling in the design of phos
Molecular modeling in the design of phospholipase A2 inhibitors
✍ William C. Ripka; William J. Sipio; William G. Galbraith πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 393 KB

The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm