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Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic

โœ Scribed by Suckling, Keith E

Book ID
118048515
Publisher
Informa plc
Year
2009
Tongue
English
Weight
270 KB
Volume
18
Category
Article
ISSN
1354-3784

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Molecular modeling in the design of phos
Molecular modeling in the design of phospholipase A2 inhibitors
โœ William C. Ripka; William J. Sipio; William G. Galbraith ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 393 KB

The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm