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Phosphoinositide-3-kinases (PI3Ks): Combined Comparative Modeling and 3D-QSAR To Rationalize the Inhibition of p110α

✍ Scribed by Frédérick, Raphaël; Denny, William A.


Book ID
121238114
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
890 KB
Volume
48
Category
Article
ISSN
0095-2338

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✍ Rommel, Christian; Vanhaesebroeck, Bart; Vogt, Peter K. 📂 Article 📅 2010 🏛 Springer Berlin Heidelberg 🌐 German ⚖ 353 KB

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost inva