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Phosphatidic acids and derivatives. IX. A new synthesis of glycolkephalins and glycerol-α-kephalins

✍ Scribed by M. A. Hoefnagel; L. J. Stegerhoek; P. E. Verkade

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
592 KB
Volume
79
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

A new synthesis of glycerol‐α‐kephalins and glycolkephalins is described. The corresponding silver benzyl diacylglycerol‐α‐phosphate or silver benzyl glycolphosphate is boiled in benzene solution with 2‐(dibenzylamino)ethyl bromide, and the O,N,N‐tribenzyl derivative of the kephalin thus obtained is converted into the kephalin by hydrogenolysis. The overall yields are 80‐90 %.

📜 SIMILAR VOLUMES

Phosphatidic acids and derivatives: XI.
Phosphatidic acids and derivatives: XI. Infra-red spectra of glycerol-α-kephalins and glycolkephalins
✍ A. van Veen; P. E. Verkade 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 330 KB

## Abstract In the present paper we are publishing the infra‐red spectra of glycerol‐α‐kephalins and glycolkephalins synthesized in our laboratory. These spectra are discussed in relation with spectra of glycerol‐α‐kephalins already available in the literature.

Phosphatidic acids and derivatives: X. D
Phosphatidic acids and derivatives: X. Diastereoisomerism with O,N,N-tribenzyl-glycerol-α-kephalins
✍ M. A. Hoefnagel; L. J. Stegerhoek; P. E. Verkade 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 237 KB

## Abstract __O,N,N__‐tribenzyl‐glycerol‐α‐kephalins have been obtained in two diastereoisomeric forms. Upon hydrogenolysis the two isomers give the same kephalin. This diastereoisomerism, due to the presence of an asymmetric carbon atom and an asymmetric phosphorus atom, is discussed in some deta