Phosphate repression of cephamycin and clavulanic acid production byStreptomyces clavuligerus
✍ Scribed by Ahmed Lebrihi; Pierre Germain; Gérard Lefebvre
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 437 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1432-0614
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Palm and palm-kernel oils and their olein and stearin fractions were suitable as the main carbon sources for growth and production of clavulanic acid by Streptomyces clavuligerus. However, oleic and lauric acids were not utilized for growth. A spontaneous mutant, which was selected for higher cepham
A high concentration of potassium phosphate (75-100 mM) stabilized pH and supported extensive growth of Streptomyces clavuligerus in a chemically defined medium; such a concentration also inhibited cephalosporin production. Although Tris buffer was found to have detrimental effects on growth and ant