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Phorbol esters have a dual action through protein kinase C in regulation of proliferation of FRTL-5 cells

✍ Scribed by Kaoru Takada; Nobuyuki Amino; Toru Tetsumoto; Kiyoshi Miyai


Book ID
115921281
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
309 KB
Volume
234
Category
Article
ISSN
0014-5793

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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo