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Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C

โœ Scribed by Yoko S. Kaneko; Kyoji Ikeda; Makoto Nakanishi


Book ID
117176534
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
565 KB
Volume
65
Category
Article
ISSN
0024-3205

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Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind