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Activation of protein kinase C by phorbol esters induces DNA synthesis and protein phosphorylations in glomerular mesangial cells

✍ Scribed by Marc Issandou; Jean-Marie Darbon

Book ID
115924709
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
815 KB
Volume
281
Category
Article
ISSN
0014-5793

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✍ B. C. Harrison; P. L. Mobley πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 947 KB

## Abstract Treatment with 300 nM phorbol 12‐myristate 13‐acetate (PMA) transforms polygonal‐shaped cultured astrocytes into process‐bearing cells and produces a shift in protein kinase C (PK‐C) from the cytosol to the membrane. Exposure to PMA also produces increases in the phosphorylation of seve