## Abstract Overexpression of ornithine decarboxylase (ODC) is an important oncogenic event in tumorigenesis. Although __ODC__ was one of the first genes described whose product is inducible by 12β__O__βtetradecanoylphorbolβ13βacetate (TPA), the mechanisms of __ODC__ transcriptional regulation have
β¦ LIBER β¦
Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells
β Scribed by Andrew P. Butler; Penny K. Mar; Frances F. McDonald; Raechelle L. Ramsay
- Book ID
- 115892571
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 968 KB
- Volume
- 194
- Category
- Article
- ISSN
- 0014-4827
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In this study we examined the action of phorbol esters, several phospholipases and retinoids on t h e induction of ornithine decarboxylase (ODC) activity in rat tracheal epithelial cells. 12-0-Tetradecanoylphorbol-13-acetate (TPA) induces ODC activity in these cells in a dose-and time-dependent mann
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