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Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices

✍ Scribed by E. Shirish Shenolikar; William Karbon; Salvatore J. Enna

Book ID
117056931
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
411 KB
Volume
139
Category
Article
ISSN
0006-291X

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Induction of protein kinase C down-regul
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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo