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Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

✍ Scribed by Antonio P. Palumbo; Mario Boccadoro; Silvano Battaglio; Paolo Corradini; Bruna Giovinazzo; Giancarlo Avanzi; Giuseppe Ponzio


Book ID
119104242
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
163 KB
Volume
39
Category
Article
ISSN
0165-4608

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Molecular confirmation of BCR-ABL fusion
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W e performed molecular studies to resolve the status of BCR and ABL in the bone marrow cells of a CML patient with a Ph chromosome resulting from a complex translocation involving chromosomes 9, 15, and 22. D N A digestion with BomHI, Hindlll, and Bglll, followed by hybridization to a bcr-specific