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Phase II trial of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea in small cell cancer of the lung

Book ID
122356577
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
96 KB
Volume
1
Category
Article
ISSN
0169-5002

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A phase II trial of 1-(2-chloroethyl)-3-
A phase II trial of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea (PCNU, NSC 95466) in recurrent malignant brain tumors
โœ Lynn G. Feun; David J. Stewart; Milam E. Leavens; M. Andrew Burgess; Niramol Sav ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer US ๐ŸŒ English โš– 264 KB

Twenty-nine with patients recurrent primary malignant brain tumors were treated with 1-(2-chlorethyl)-3-(2,6-dioxo-3-piperidyl)-l-nitrosourea (PCNU) at an initial dose of 110 mg/m 2 with subsequent doses determined by the degree of delayed toxicity. The interval between treatments was usually weeks.

Determination of 1-(2-chloroethyl)-3-(2,
Determination of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea in plasma by negative chemical ionization mass spectrometry
โœ Ronald G. Smith; Lily K. Cheung; Lynn G. Feun; Ti Li Loo ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 353 KB

A sensitive and specific method for the quantitative determination of a new antitumor agent, 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-l-nitrosourea, (PCNU) has been developed for the analysis of ,plasma. This assay involves extraction of the plasma sample, separation of the drug by thin-layer chr