✦ LIBER ✦

Determination of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea in plasma by negative chemical ionization mass spectrometry

✍ Scribed by Ronald G. Smith; Lily K. Cheung; Lynn G. Feun; Ti Li Loo

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 353 KB
Volume: 10
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200100704

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✦ Synopsis

A sensitive and specific method for the quantitative determination of a new antitumor agent, 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-l-nitrosourea, (PCNU) has been developed for the analysis of ,plasma. This assay involves extraction of the plasma sample, separation of the drug by thin-layer chromatography and mass spectrometric detection of the negative ions derived from the unchanged drug and its *H,-laheled analog. Ion current profile peaks are obtained when drug samples are introduced into the heated source using a desorption chemical ionization probe. Detection limits are below 1.0 ng ml-' of plasma. This method has been applied to determine the in uitro rate of decomposition of PCNU in plasma and the plasma clearance of this drug from a cancer patient.

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