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Phase II study of XR 5000, an inhibitor of topoisomerases I and II, in advanced colorectal cancer

โœ Scribed by F Caponigro; C Dittrich; J.B Sorensen; J.H.M Schellens; F Duffaud; L Paz Ares; D Lacombe; C de Balincourt; P Fumoleau


Book ID
117657433
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
89 KB
Volume
38
Category
Article
ISSN
0959-8049

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Phase I-II study of ftorafur and methyl-
โœ Robert J. Belt; Ronald Stephens ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 316 KB ๐Ÿ‘ 2 views

The combination of Ftorafur (NSC-148958) and methyl-CCNU (NSC-95441) was evaluated in 36 patients with advanced colorectal cancer. The principle toxicities encountered were myelosuppression, gastrointestinal, and neurological. There were no complete responses and only 5/34 (14.7%) patients achieved