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Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer*

✍ Scribed by Christian Dittrich; Veronique Dieras; Pierre Kerbrat; Cornelis Punt; Roberto Sorio; Francesco Caponigro; Xavier Paoletti; Christine de Balincourt; Denis Lacombe; Pierre Fumoleau


Book ID
111551010
Publisher
Springer US
Year
2003
Tongue
English
Weight
65 KB
Volume
21
Category
Article
ISSN
0167-6997

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A Phase II trial of aprinocarsen, an ant
✍ Ranjana Advani; Prema Peethambaram; Bert L. Lum; George A. Fisher; Lynn Hartmann πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 77 KB

## Abstract ## BACKGROUND It has been postulated that protein kinase C Ξ± (PKC‐α) plays a pivotal role in signal transduction in tumor cancer cells. Aprinocarsen, a 20‐base antisense oligonucleotide, has shown ability to inhibit PKC‐α protein expression and inhibit tumor growth in human xenograft m