## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and gemcitabine have single‐agent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie
Phase II multicenter open-label study of carboplatin and pegylated liposomal doxorubicin in uterine and cervical malignancies
✍ Scribed by L.H. LÊ; K.D. SWENERTON; L. ELIT; D.M. PROVENCHER; G.C.E. STUART; T. LE; U. LEE; A. RODGERS; G.R. POND; H. HU; A.M. OZA
- Book ID
- 109085314
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 102 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1048-891X
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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and docetaxel have single‐agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with ad
## BACKGROUND. The activity of the combination of carboplatin and liposomal doxorubicin was tested in a Phase II study of patients with recurrent cervical carcinoma. ## METHODS. The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starti