Phase I trials of targeted anticancer drugs: a need to refocus
β Scribed by Borden, Ernest C.; Dowlati, Afshin
- Book ID
- 118049554
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 89 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrd3909
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π SIMILAR VOLUMES
The traditional approach to conducting Phase I studies of anticancer drugs is to select a starting dosage for humans based on preclinical data (e.g., mg equivalent of 1/10 LD10 in mice), then empirically escalate dosages in cohorts of patients until the maximum tolerated dosage (MTD) is established.
Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-bromopyridines in the presence of the complex base NaNH2-tBuONa. A few chemical properties of these new heterocycles are reported, as well as their antitumoral activity.