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Phase I trials of targeted anticancer drugs: a need to refocus

✍ Scribed by Borden, Ernest C.; Dowlati, Afshin


Book ID
118049554
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
89 KB
Volume
11
Category
Article
ISSN
1474-1776

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πŸ“œ SIMILAR VOLUMES


Concept of maximum tolerated systemic ex
✍ Evans, William E. ;Rodman, John H. ;Relling, Mary V. ;Crom, William R. ;Rivera, πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 653 KB

The traditional approach to conducting Phase I studies of anticancer drugs is to select a starting dosage for humans based on preclinical data (e.g., mg equivalent of 1/10 LD10 in mice), then empirically escalate dosages in cohorts of patients until the maximum tolerated dosage (MTD) is established.

Design of new anticancer drugs. I. Easy
✍ Ivan Rodriguez; Catherine Kuehm-CaubΓ¨re; Karine Vinter-Pasquier; Pierre Renard; πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 164 KB

Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-bromopyridines in the presence of the complex base NaNH2-tBuONa. A few chemical properties of these new heterocycles are reported, as well as their antitumoral activity.