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Design of new anticancer drugs. I. Easy hetarynic access to dihydrodipyridopyrazines, a new family of antitumor agents

✍ Scribed by Ivan Rodriguez; Catherine Kuehm-Caubère; Karine Vinter-Pasquier; Pierre Renard; Bruno Pfeiffer; Paul Caubère

Book ID: 104259891
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 164 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01558-5

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✦ Synopsis

Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-bromopyridines in the presence of the complex base NaNH2-tBuONa. A few chemical properties of these new heterocycles are reported, as well as their antitumoral activity.

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