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Design of new anticancer drugs. II. Easy arynic access to benzocyclobutacarbazoles, a new family of antitumor agents

✍ Scribed by Stéphanie Christophe; Catherine Kuehm-Caubère; Pierre Renard; Bruno Pfeiffer; Paul Caubère


Book ID
108387220
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
181 KB
Volume
39
Category
Article
ISSN
0040-4039

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Design of new anticancer drugs. I. Easy
✍ Ivan Rodriguez; Catherine Kuehm-Caubère; Karine Vinter-Pasquier; Pierre Renard; 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 164 KB

Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-bromopyridines in the presence of the complex base NaNH2-tBuONa. A few chemical properties of these new heterocycles are reported, as well as their antitumoral activity.