The traditional approach to conducting Phase I studies of anticancer drugs is to select a starting dosage for humans based on preclinical data (e.g., mg equivalent of 1/10 LD10 in mice), then empirically escalate dosages in cohorts of patients until the maximum tolerated dosage (MTD) is established.
β¦ LIBER β¦
Recent application of analytical methods to phase I and phase II drugs development: a review
β Scribed by Marcello Locatelli; Luciana Governatori; Giuseppe Carlucci; Salvatore Genovese; Adriano Mollica; Francesco Epifano
- Book ID
- 112013356
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 371 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0269-3879
- DOI
- 10.1002/bmc.1674
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Concept of maximum tolerated systemic ex
β
Evans, William E. ;Rodman, John H. ;Relling, Mary V. ;Crom, William R. ;Rivera,
π
Article
π
1991
π
John Wiley and Sons
π
English
β 653 KB
A method of analytic phase correction in
β
Koichi Sano; Tetsuo Yokoyama; Shinichi Sato; Hideaki Koizumi
π
Article
π
1988
π
John Wiley and Sons
π
English
β 846 KB
Topical application of WR-2721 to preven
β
Gusfavo S. Montana; Mitchell S. Anscher; Charles M. Mansbach II; Nicolas Duly; M
π
Article
π
1992
π
John Wiley and Sons
π
English
β 439 KB
Patients undergoing x-ray therapy to the pelvis have intestinal symptoms proportional to the volume treated and the dose delivered. WR-2721, S-2 (3-aminopropylaminoethyl) phosphorothioic acid, is an organic thiophosphate compound that selectively protects normal tissues against radiation effects. A
Application of aqueous two-phase systems
β
Pamela da Rocha PatrΓcio; Maiby Cabral Mesquita; Luis Henrique Mendes da Silva;
π
Article
π
2011
π
Elsevier Science
π
English
β 386 KB
Development and validation of a reversed
β
Vinay Kumar Venishetty; Chandrasekar Durairaj; Ramakrishna Sistla; Madhusudhan R
π
Article
π
2007
π
John Wiley and Sons
π
English
β 191 KB
π 2 views
Applications of Oxygen Polarography to D
β
Michael J. Kaufman
π
Article
π
1990
π
Springer US
π
English
β 662 KB