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Recent application of analytical methods to phase I and phase II drugs development: a review

✍ Scribed by Marcello Locatelli; Luciana Governatori; Giuseppe Carlucci; Salvatore Genovese; Adriano Mollica; Francesco Epifano


Book ID
112013356
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
371 KB
Volume
26
Category
Article
ISSN
0269-3879

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πŸ“œ SIMILAR VOLUMES


Concept of maximum tolerated systemic ex
✍ Evans, William E. ;Rodman, John H. ;Relling, Mary V. ;Crom, William R. ;Rivera, πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 653 KB

The traditional approach to conducting Phase I studies of anticancer drugs is to select a starting dosage for humans based on preclinical data (e.g., mg equivalent of 1/10 LD10 in mice), then empirically escalate dosages in cohorts of patients until the maximum tolerated dosage (MTD) is established.

Topical application of WR-2721 to preven
✍ Gusfavo S. Montana; Mitchell S. Anscher; Charles M. Mansbach II; Nicolas Duly; M πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 439 KB

Patients undergoing x-ray therapy to the pelvis have intestinal symptoms proportional to the volume treated and the dose delivered. WR-2721, S-2 (3-aminopropylaminoethyl) phosphorothioic acid, is an organic thiophosphate compound that selectively protects normal tissues against radiation effects. A