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Phase I study of the cytotoxic agent N -[2-(dimethylamino)ethyl]acridine-4-carboxamide

✍ Scribed by Michael R. McCrystal; Barrie D. Evans; Vernon J. Harvey; Paul I. Thompson; David J. Porter; Bruce C. Baguley


Book ID
105994501
Publisher
Springer
Year
1999
Tongue
English
Weight
115 KB
Volume
44
Category
Article
ISSN
0344-5704

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A new synthesis of substituted acridine-
✍ Swarna A. Gamage; Julie A. Spicer; Gordon W. Rewcastle; William A. Denny πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 201 KB

A new synthesis of substituted acridine-4-carboxylic acids 2 from methyl 2-[N-(2-earboxyphenyl)amino]benzoates (4) is reported, via NaBH4 reduction of the corresponding imidazolides (5), oxidation of the resulting alcohols 6 to aldehydes 7, and cyclisation of these with trifluoroacetic acid to the m