✦ LIBER ✦

Cytotoxic and DNA-Damaging Properties of N-[2-(Dimethylamino)ethyl]acridine-4-Carboxamide (DACA) and Its Analogues

✍ Scribed by Elżbieta Pastwa; Ewa Ciesielska; Mariola K Piestrzeniewicz; William A Denny; Marek Gniazdowski; Leszek Szmigiero

Book ID: 113994045
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 457 KB
Volume: 56
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(98)00030-6

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A new synthesis of substituted acridine-

A new synthesis of substituted acridine-4-carboxylic acids and the anticancer drug N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA)

✍ Swarna A. Gamage; Julie A. Spicer; Gordon W. Rewcastle; William A. Denny 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 201 KB

A new synthesis of substituted acridine-4-carboxylic acids 2 from methyl 2-[N-(2-earboxyphenyl)amino]benzoates (4) is reported, via NaBH4 reduction of the corresponding imidazolides (5), oxidation of the resulting alcohols 6 to aldehydes 7, and cyclisation of these with trifluoroacetic acid to the m

ChemInform Abstract: A New Synthesis of

ChemInform Abstract: A New Synthesis of Substituted Acridine-4-carboxylic Acids and the Anticancer Drug N-(2-(Dimethylamino)ethyl)acridine-4-carboxamide (DACA) .

✍ S. A. GAMAGE; J. A. SPICER; G. W. REWCASTLE; W. A. DENNY 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Inter-species variation in the metabolis

Inter-species variation in the metabolism and inhibition of N-[(2′-dimethylamino)ethyl]acridine-4-carboxamide (DACA) by aldehyde oxidase

✍ Philip C Schofield; Iain G.C Robertson; James W Paxton 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 208 KB

Mechanism of cytotoxicity of N -[2-(dime

Mechanism of cytotoxicity of N -[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II

✍ David J. A. Bridewell; Graeme J. Finlay; Bruce C. Baguley 📂 Article 📅 1999 🏛 Springer 🌐 English ⚖ 183 KB

An investigation into the formation of N

An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells

✍ Kay Padget; Alistair Stewart; Peter Charlton; Michael J Tilby; Caroline A Austin 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 301 KB

Major Groove Binding and ‘DNA-Induced' F

Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N -(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG) 2 at 1.3-Å Resolution

✍ Todd, Alan K.; Adams, Adrienne; Thorpe, James H.; Denny, William A.; Wakelin, La 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 212 KB