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Mechanism of cytotoxicity of N -[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II

✍ Scribed by David J. A. Bridewell; Graeme J. Finlay; Bruce C. Baguley


Book ID
105994460
Publisher
Springer
Year
1999
Tongue
English
Weight
183 KB
Volume
43
Category
Article
ISSN
0344-5704

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A new synthesis of substituted acridine-
✍ Swarna A. Gamage; Julie A. Spicer; Gordon W. Rewcastle; William A. Denny πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 201 KB

A new synthesis of substituted acridine-4-carboxylic acids 2 from methyl 2-[N-(2-earboxyphenyl)amino]benzoates (4) is reported, via NaBH4 reduction of the corresponding imidazolides (5), oxidation of the resulting alcohols 6 to aldehydes 7, and cyclisation of these with trifluoroacetic acid to the m