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Phase I Study of Oral Gemcitabine Prodrug (LY2334737) Alone and in Combination with Erlotinib in Patients with Advanced Solid Tumors

✍ Scribed by Koolen, S. L. W.; Witteveen, P. O.; Jansen, R. S.; Langenberg, M. H. G.; Kronemeijer, R. H.; Nol, A.; Garcia-Ribas, I.; Callies, S.; Benhadji, K. A.; Slapak, C. A.; Beijnen, J. H.; Voest, E. E.; Schellens, J. H. M.


Book ID
126265135
Publisher
American Association for Cancer Research
Year
2011
Tongue
English
Weight
378 KB
Volume
17
Category
Article
ISSN
1078-0432

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi