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Phase I Study of Intravenous PSC-833 and Doxorubicin: Reversal of Multidrug Resistance

✍ Scribed by Minami, Hironobu ;Ohtsu, Tomoko ;Fujii, Hirofumi ;Igarashi, Tadahiko ;Itoh, Kuniaki ;Uchiyama-Kokubu, Noriko ;Aizawa, Tetsushi ;Watanabe, Torn ;Uda, Yoshinori ;Tanigawara, Yusuke ;Sasaki, Yasutsuna

Book ID
108581992
Publisher
Wiley (Blackwell Publishing)
Year
2001
Tongue
English
Weight
133 KB
Volume
92
Category
Article
ISSN
0910-5050

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## Abstract The cyclosporin SDZ PSC 833 (PSC) is a potent __in vivo__ chemosensitizer for tumor cells with P‐glycoprotein(Pgp)‐dependent multidrug resistance (MDR). However, Pgp expression also occurs in CD8^+^ T cells, NK cells, macrophages and stem cells. In order to find whether PSC might displa