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Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

โœ Scribed by M. Lemaire; Armin Bruelisauer; Pierrette Guntz; Hitoshi Sato


Publisher
Springer
Year
1996
Tongue
English
Weight
277 KB
Volume
38
Category
Article
ISSN
0344-5704

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๐Ÿ“œ SIMILAR VOLUMES


SDZ PSC 833, A non-immunosuppressive cyc
โœ Roland P. Keller; Hans J. Altermatt; Kees Nooter; Guenter Poschmann; Jean A. Lai ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 637 KB

Cyclosporin A (CsA, Sandimmune) is known to reverse P-glycoprotein(P-gp I70)mediated multidrug resistance as efficiently as other prototype compounds of resistance modifiers. The immunosuppressive activity and nephrotoxicity of CsA, however, may limit its clinical use. PSC-833, a new cyclosporine, e