Phase I study of carboplatin in combination with gemcitabine and irinotecan in patients with solid tumors : Preliminary evidence of activity in small cell and neuroendocrine carcinomas
β Scribed by Gilberto de Lima Lopes Jr.; Alberto Chiappori; George Simon; Eric Haura; Dan Sullivan; Scott Antonia; Michel Langevin; Richard Lush; Caio Max Rocha-Lima
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 81 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0008-543X
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A Phase I study was initiated to determine the maximum tolerated dose of weekly gemcitabine combined with monthly, fixed-dose docetaxel. ## METHODS. Patients with metastatic solid tumors were treated with docetaxel, 60 mg/m 2 , on Day 1 every 28 days. Gemcitabine was administered on Days 1, 8, and