## Abstract ## BACKGROUND The authors performed a dose escalation study of cisplatin and the novel deoxycytidine analog, tezacitabine, to determine the maximum tolerated dose of the combination. ## METHODS Twentyβthree patients with advanced cancer and good performance status were accrued to 3 d
Phase I dose-escalation study of tezacitabine in combination with 5-fluorouracil in patients with advanced solid tumors
β Scribed by Johanna C. Bendell; Joseph P. Eder; Jeffrey W. Clark; Panagiotis Fidias; Thomas J. Lynch; Michael V. Seiden; David P. Ryan
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 84 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and doseβlimiting toxicities (DLTs) of bortezomib in combi
## Abstract ## BACKGROUND Metastatic melanoma (MM) is associated with a high risk of central nervous system (CNS) metastases, and current chemotherapy does not adequately treat or protect patients with MM against CNS metastases. Therefore, the authors initiated a Phase I study to determine the pha