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Phase I evaluation of vindesine in children: A southwest oncology group pilot study

✍ Scribed by Komp, Diane ;Vats, Tribhawan ;Shepherd, Dell A. ;Vietti, Teresa ;Hoogstraten, Barth ;Haas, Charles D.

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
374 KB
Volume
8
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Twenty‐one children (19 with leukemia) were given 34 courses of vindesine on a weekly or twice‐weekly schedule in escalating doses. Thirty‐three courses were fully or partially evaluable for response and/or toxicity. Granulocyto‐penia was the dose‐limiting toxicity. Transient jaw, neck, or bone pain was common after each dose. Motor weakness, paresthesias, and constipation were neither frequent nor severe. In this Phase I study, vindesine had some antileu‐kemia activity in children previously treated with vincristine and other drugs. Phase II studies are warranted and a starting dose of 1.85 mg/m^2^ twice weekly appears tolerable.

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