Phase I Clinical Trial and Pharmacokinetics of Intravesical Mitomycin C in Dogs with Localized Transitional Cell Carcinoma of the Urinary Bladder
โ Scribed by A.H. Abbo; D.R. Jones; A.R. Masters; J.C. Stewart; L. Fourez; D.W. Knapp
- Book ID
- 118095262
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 182 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0891-6640
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We treated 47 patients with recurrent transitional cell carcinoma of the bladder with intravesical chemotherapy. Twenty milligrams of mitomycin C per treatment was introduced 7 days after transurethral resection (TUR) or diagnostic cystoscopy, and was repeated at 2-week intervals for five times foll
Mitomycin C was administered t o 21 patients with metastatic transitional cell carcinoma of the urinary bladder. O f these, 19 patients were evaluable. Objective response occurred in f o u r patients, or 21 %. Hemopoietic depression was common and was dose related. Nephrotoxicity related t o the dr