๐”– Bobbio Scriptorium
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Mitomycin c in the treatment of metastatic transitional cell carcinoma of urinary bladder

โœ Scribed by K. Early; E. G. Elias; A. Mittelman; D. Albert; G. P. Murphy

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
515 KB
Volume
31
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Mitomycin C was administered t o 21 patients with metastatic transitional cell carcinoma of the urinary bladder. O f these, 19 patients were evaluable.

Objective response occurred in f o u r patients, or 21 %. Hemopoietic depression was common and was dose related. Nephrotoxicity related t o the drug was seen in one case. Mitomycin C does exhibit a n t i t u m o r activity against transitional cell carcinoma in man.

ITOMYCIN c IS A N ANTIBIOTIC ISOLATED M from the broth of Streptomyces caespitosus.l It has cytotoxic effects similar to that of other alkylating agents and has been used in the treatment of a wide variety of metastatic diseases, but not in transitional cell carcinoma.

Our experience with metastatic transitional cell carcinoma of the urinary bladder has been discouraging. A recent review of 161 patients with Stage D tumors from our Institute showed a mean survival of 10.4 months.2 These patients had been mainly treated with radiation therapy and 5-fluorouracil. Silber,3 Liu et al;4 and Prout and Marshall5 have shown that patients with advanced stages of carcinoma of the bladder show no difference in survival whether they received treatment or not.

Because of these poor results in the treatment of vesical cancer, we sought newer methods of treatment. Kaufman6 had shown that

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