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Phase I clinical evaluation of [SP-4-3(R)]-[1,1-cyclobutanedicarboxylato(2-)](2-methyl-1,4-butanediamine-N,N1) platinum in patients with metastatic solid tumors

✍ Scribed by Richard L. Theriault; I. A. Cohen; Laura Esparza; C. Kowal; Martin N. Raber


Book ID
104886914
Publisher
Springer
Year
1993
Tongue
English
Weight
437 KB
Volume
31
Category
Article
ISSN
0344-5704

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## Abstract Starting from the chiral compound 1, (R)‐(+)‐2‐methyl‐1,4‐[^14^C]butanediamine 7 was synthesized in a sequence of reactions in which ^14^C‐label was introduce using label potassium cyanide. Compound 7 was reacted with potassium tetraiodoplatinate and silver 1,1‐cyclobutanedicarboxylate