Phase I and II clinical trial design for targeted agents
โ Scribed by Richard L. Schilsky
- Book ID
- 107384265
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 151 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1776-2596
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at
Early termination of clinical trials is advisable if initial evidence indicates the treatment under study is ineffective. Predictive probability methods permit the construction of multistage studies that allow for early termination while still controlling overall false-positive (declare an ineffecti