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Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study

✍ Scribed by Michael D. Prados; W. K. A. Yung; Patrick Y. Wen; Larry Junck; Timothy Cloughesy; Karen Fink; Susan Chang; H. Ian Robins; Janet Dancey; John Kuhn

Publisher
Springer
Year
2007
Tongue
English
Weight
325 KB
Volume
61
Category
Article
ISSN
0344-5704

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Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma : A North American Brain Tumor Consortium trial
✍ Susan M. Chang; Michael D. Prados; W. K. Alfred Yung; Howard Fine; Larry Junck; πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 77 KB

## Abstract ## BACKGROUND Temozolomide (TMZ) and 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea (BCNU) are reported to be active agents in anaplastic glioma (AG). TMZ has also been shown to deplete alkyltransferase, a DNA repair enzyme that contributes to nitrosourea resistance. The objective of the curre