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A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas

✍ Scribed by Nicholas Butowski; Kathleen R. Lamborn; Bee L. Lee; Michael D. Prados; Timothy Cloughesy; Lisa M. DeAngelis; Lauren Abrey; Karen Fink; Frank Lieberman; Minesh Mehta; H. Ian Robins; Larry Junck; Andres M. Salazar; Susan M. Chang

Publisher
Springer US
Year
2008
Tongue
English
Weight
188 KB
Volume
91
Category
Article
ISSN
0167-594X

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✍ Susan M. Chang; Michael D. Prados; W. K. Alfred Yung; Howard Fine; Larry Junck; πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 77 KB

## Abstract ## BACKGROUND Temozolomide (TMZ) and 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea (BCNU) are reported to be active agents in anaplastic glioma (AG). TMZ has also been shown to deplete alkyltransferase, a DNA repair enzyme that contributes to nitrosourea resistance. The objective of the curre