𝔖 Bobbio Scriptorium
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Pharmacophore Identification of Hydroxamate HDAC 1 Inhibitors

✍ Scribed by Liqin YU; Fei LIU; Yadong CHEN; Qidong YOU


Book ID
102099675
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
185 KB
Volume
27
Category
Article
ISSN
0256-7660

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## Abstract An β€˜active analog’ approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV‐1 reverse transcriptase. The preliminary results indicate that the O2, O4β€², and O5β€² atoms are capable of adopting a unique pharmacophoric patte