Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase

✍ Scribed by Mark A. Fisher; Prem N. S. Yadav; Janardan Yadav; David Kristol; Edward Arnold; Mukund J. Modak

• Book ID: 102372383
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 493 KB
• Volume: 7
• Category: Article
• ISSN: 0952-3499
• DOI: 10.1002/jmr.300070309

✦ Synopsis

Abstract

An ‘active analog’ approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV‐1 reverse transcriptase. The preliminary results indicate that the O2, O4′, and O5′ atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.