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Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms

✍ Scribed by Fentress, H M; Grinde, E; Mazurkiewicz, J E; Backstrom, J R; Herrick-Davis, K; Sanders-Bush, E


Book ID
110075392
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
253 KB
Volume
5
Category
Article
ISSN
1470-269X

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Transgenic mice lacking a functional 5-HT 2c receptor gene are extremely susceptible to audiogenic seizures, suggesting that 5-HT 2c receptors mediate inhibition of neuronal network excitability. The present association study tested the hypothesis that a Cys23Ser substitution polymorphism within the